diff --git a/CHANGELOG.md b/CHANGELOG.md
index c79674c..2e30bb6 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -18,6 +18,7 @@ The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/).
 - Fix extraction of jbig2 files, which was producing invalid files ([#652](https://github.com/pdfminer/pdfminer.six/pull/653))
 - Crash in `pdf2txt.py --boxes-flow=disabled` ([#682](https://github.com/pdfminer/pdfminer.six/pull/682))
 - Only use xref fallback if `PDFNoValidXRef` is raised and `fallback` is True ([#684](https://github.com/pdfminer/pdfminer.six/pull/684))
+- Ignore empty characters when analyzing layout ([#499](https://github.com/pdfminer/pdfminer.six/pull/499))
 
 ### Changed
 - Replace warnings.warn with logging.Logger.warning in line with [recommended use](https://docs.python.org/3/howto/logging.html#when-to-use-logging) ([#673](https://github.com/pdfminer/pdfminer.six/pull/673))
diff --git a/pdfminer/layout.py b/pdfminer/layout.py
index 3b84ce6..9196a88 100644
--- a/pdfminer/layout.py
+++ b/pdfminer/layout.py
@@ -504,6 +504,9 @@ class LTTextLine(LTTextContainer[TextLineElement]):
     ) -> List["LTTextLine"]:
         raise NotImplementedError
 
+    def is_empty(self) -> bool:
+        return super().is_empty() or self.get_text().isspace()
+
 
 class LTTextLineHorizontal(LTTextLine):
     def __init__(self, word_margin: float) -> None:
diff --git a/samples/contrib/issue-449-horizontal.pdf b/samples/contrib/issue-449-horizontal.pdf
new file mode 100644
index 0000000..33e08a7
Binary files /dev/null and b/samples/contrib/issue-449-horizontal.pdf differ
diff --git a/samples/contrib/issue-449-vertical.pdf b/samples/contrib/issue-449-vertical.pdf
new file mode 100644
index 0000000..bc6a76c
Binary files /dev/null and b/samples/contrib/issue-449-vertical.pdf differ
diff --git a/tests/test_layout.py b/tests/test_layout.py
index ce13fc9..fd393a4 100644
--- a/tests/test_layout.py
+++ b/tests/test_layout.py
@@ -1,12 +1,16 @@
 import unittest
 
+from pdfminer.high_level import extract_pages
 from pdfminer.layout import (
     LTLayoutContainer,
     LAParams,
     LTTextLineHorizontal,
     LTTextLineVertical,
+    LTTextBoxHorizontal,
+    LTTextBoxVertical,
 )
 from pdfminer.utils import Plane
+from helpers import absolute_sample_path
 
 
 class TestGroupTextLines(unittest.TestCase):
@@ -107,3 +111,38 @@ class TestFindNeigbors(unittest.TestCase):
                 centrally_aligned_overlapping,
             ],
         )
+
+
+def test_pdf_with_empty_characters_horizontal():
+    """Regression test for issue #449
+
+    See: https://github.com/pdfminer/pdfminer.six/pull/689
+
+    The page aggregator should separate the 3 horizontal lines in the
+    sample PDF. The used PDF sample has multiple explicit space characters
+    in between lines with text.
+    """
+    path = absolute_sample_path("contrib/issue-449-horizontal.pdf")
+    pages = extract_pages(path)
+    textboxes = [
+        textbox for textbox in next(pages) if isinstance(textbox, LTTextBoxHorizontal)
+    ]
+    assert len(textboxes) == 3
+
+
+def test_pdf_with_empty_characters_vertical():
+    """Regression test for issue #449
+
+    See: https://github.com/pdfminer/pdfminer.six/pull/689
+
+    The page aggregator should separate the 3 horizontal lines in the
+    sample PDF. The used PDF sample has multiple explicit space characters
+    in between lines with text.
+    """
+    path = absolute_sample_path("contrib/issue-449-vertical.pdf")
+    laparams = LAParams(detect_vertical=True)
+    pages = extract_pages(path, laparams=laparams)
+    textboxes = [
+        textbox for textbox in next(pages) if isinstance(textbox, LTTextBoxVertical)
+    ]
+    assert len(textboxes) == 3